I just read an excellent article on MDLinx.com that talks about a recent study where scientists use Nanoparticles to deliver anti0inflammatory medicine right to the damaged cell! Common anti-inflamatory medicines target the whole body and can sometimes cause severe side effects. As someone with Ankylosing Spondylitis who has tried many different meds, I am ready for this technology now. Sign me up! Check out the full article here:
Posts Tagged ‘Enthesitis ankylosing spondylitis’
Pig Worms and Auto Immune Disease? Heck No! …well- Maybe
Chronic pain can be a great motivator. I am currently on the no-starch diet to decrease my inflammation and i have to say, that’s not too far off from pig worms if you ask me. Basically just cut out all the food you like. Anyway, If you had a rheumatoid arthritis or Crohn’s disease, and swallowing the eggs of a pig parasite might help, could you do it?
Their is a team at Coronado Biosciences Inc that is banking on it.
The Massachusetts company is developing what it hopes will be a new class of treatments for autoimmune conditions. The dosage consists of thousands of microscopic parasite eggs, taken from pig feces, and added to a tablespoon of saline solution. You take it like you would cough syrup.
“In a pig, the eggs would grow into mature whipworms and reproduce, without harming their host. In humans, the same eggs barely survive two weeks.” Yet in that short amount of time it seems that they are actually changing the immune system and retraining it to prevent it from attacking the body’s own organs.
This has huge potential into what has been a difficult disease process to nail down. Dr. Joel Weinstock, Chief of gastroenterology and hepatology puts it like this, “It has the potential not only to be a drug but to provide insight into the cause of these diseases. The company is preparing to enroll 220 patients with Crohn’s disease in a midstage clinical trial. Participants will receive either a dose with 7,500 eggs from a pig whipworm or a placebo once every two weeks for 12 weeks.”
It sounds tough, and I don’t think i would offer to be a guniea pig, but like I said, Pain is a great motivator. Is your
What do you think?
Enthesitis and my Podiatrist visit
Yesterday I went to the podiatrist for the second time to treat my foot and achilles tendon pain. I tried a local doctor and he was excellent. I have Ankylosing Spondylitis so i see my fair share of physicians, and there has been a wide range of competency and caring. This guy was a winner. He took the time to explain things, provide options and I felt like he genuinely cared about my treatment.
Anyway, he said that I had plantar fasciitis and enthesitis. He provided 5 different treatment options: cortisone shot, foot splint, foot cast, physical therapy and stretching. I went with the cortisone shot and night splint. I have had many cortisone shots with my AS and let me tell you…this shot was interesting! It wasn’t as painful as some of the joint shots, but the doctor really had to slam it in to go through the padding in my foot. It is sore today, but I will update on it’s impact of my Enthesitis and Plantar Fasciitis.
Regarding the enthesisits of the Achilles Tendon… i asked for a cortisone shot there also, but he stated that he would never do that because of the risk of rupturing the achilles tendon–so if any of you see a doctor who is willing to do that, I might think twice.
What is Enthesitis?
Enthesitis is an inflammation of entheses, the site where ligaments or tendons insert into the bones. It is also known as enthesopathy, or anypathologic ailment relating to the entheses. The enthesitis is any point of connection of skeletal muscle tissues to the bone fragments, where continual stress or inflamed autoimmune disease can result in inflammation or sometimes fibrosis and calcification. The most severe enthesitis which is associated with inflammatory autoimmune ailment is at the rear foot, specially the calf muscles. It is normally only agonizing when the associated muscle is stimulated.
Enthesitis is a distinctive feature in various forms of spondylitis or spondyloarthritis. Enthesitis is neither widely present nor a dominant feature of all types of joint diseases, for example rheumatoid arthritis (generally synovitis).
Enthesitis often makes the affected region of the soft tissues to become ropey (known as fibrosis) or solid (known as ossification or calcification). It can be quite distressing; the pain occurs mostly when an individual make use of his/her muscles and try to use bones. Read the full article here.