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Nanoparticles target immune cells in inflammation

Written by mike on . Posted in Blog

I just read an excellent article on MDLinx.com that talks about a recent study where scientists use Nanoparticles to deliver anti0inflammatory medicine right to the damaged cell! Common anti-inflamatory medicines target the whole body and can sometimes  cause severe side effects. As someone with Ankylosing Spondylitis who has tried many different meds, I am ready for this technology now. Sign me up! Check out the full article here:

Enthesitis and Ankylosing Spondylitis

Written by mike on . Posted in Enthesitis Information

Ankylosing Spondylitis and relationship to Enthesitis

Ankylosing spondylitis is a serious seronegative spondyloarthropathy which mainly involves the axial skeletal system (i.e. spondylitis and sacroiliitis). The aetiology is unidentified but involves the connection of genetic and ecological factors. Obviously, enthesitis is the “infection of the enthesis, in which the joint capsules, tendons or ligaments link to the bones.” This inflammation can result in severe discomfort and pain.

In a report revealed in the journal of Rheumatology International, researchers “examined the link between enthesitis and quality-of-life factors in ankylosing spondylitis in Moroccan sufferers.” The scientific studies discovered that, “Severeness of enthesitis was considerably associated with disease activity, operational disability and wreckage of daily life.
Other clinical symptoms include peripheral joint disease, enthesitis, and extra-articular body organ engagement. It has been specified by various identities, such as rheumatoid spondylitis in the French literature and spondyloarthrite rhizomegaliquein in the American literature.

Ankylosing spondylitis is prototype of the spondyloarthropathies, a group of related diseases that also involves psoriatic arthritis (PsA), reactive arthritis (ReA), spondyloarthropathy linked to inflammatory bowel disease, undifferentiated spondyloarthropathy and also behcet disease and whipple disease. Ankylosing spondylitis is considered as a spondyloarthropathy. This disorder is usually found in relation to other spondyloarthropathies, which includes ReA, PsA, ulcerative colitis and Chronic disease. Sufferers often have a genetic history of either Ankylosing spondylitis or spondyloarthropathy.
The etiology of Ankylosing spondylitis is not comprehended completely; however, a deep hereditary predisposition exists. A direct association between Ankylosing spondylitis and the HLA-B27 has been identified. The actual purpose of HLA-B27 in stressful Ankylosing spondylitis remains unidentified; however, it is considered that HLA-B27 may appear to be or work as a receptor for a powerful inciting antigen, for example bacteria.

Enthesitis is a main clinical feature in Ankylosing spondylitis. In order to identify the condition of enthesitis in Ankylosing spondylitis with the entire level of disease, a device to evaluate disease activity needs to be selected. In 1987, a scientist has revealed a device to examine enthesitis in Ankylosing spondylitis. This device, however, is neither commonly used in daily practices nor in clinical tests. To evaluate the appropriateness of a device to assess final results, all attributes should be evaluated. However, in Ankylosing spondylitis, presently no “gold standard” is available for calibrating disease activity. Unbiased measures for example, C reactive protein and erythrocyte sedimentation rate (ESR) co-relate inadequately with scientific disease activity. Self administered survey has therefore been evolved that better demonstrates clinical disease activity in Ankylosing spondylitis. This device has been proven to be legitimate, reproducible, and reactive to alter. It is also commonly used to calculate disease activity in a 10 centimeters visual analogue scale (VAS) to be done by the sufferer and by the physician separately.

The diagnosis is completed by incorporating clinical requirements of inflammatory lumbar pain and enthesitis with radiological conclusions. Early diagnosis is necessary because early physical and medical therapy may strengthen functional results. As with any long-term disease, sufferer’s knowledge is essential to familiarize the sufferer with the signs or symptoms, course, and therapy for the disease. Treatment methods include pharmacologic, physiotherapy and surgery.

Autoimune Diseases and pig tapeworms?

Written by mike on . Posted in Blog

Pig Worms and Auto Immune Disease? Heck No! …well- Maybe

Chronic pain can be a great motivator. I am currently on the no-starch diet to decrease my inflammation and i have to say, that’s not too far off from pig worms if you ask me. Basically just cut out all the food you like. Anyway, If you had a rheumatoid arthritis or Crohn’s disease, and swallowing the eggs of a pig parasite might help, could you do it?

Their is a  team at Coronado Biosciences Inc that is banking on it.

The Massachusetts company is developing what it hopes will be a new class of treatments for autoimmune conditions. The dosage consists of thousands of microscopic parasite eggs, taken from pig feces, and added to a tablespoon of saline solution. You take it like you would cough syrup.

“In a pig, the eggs would grow into mature whipworms and reproduce, without harming their host. In humans, the same eggs barely survive two weeks.” Yet in that short amount of time it seems that they are actually changing the immune system and retraining it to prevent it from attacking the body’s own organs.

This has huge potential into what has been a difficult disease process to nail down. Dr. Joel Weinstock, Chief of gastroenterology and hepatology puts it like this, “It has the potential not only to be a drug but to provide insight into the cause of these diseases. The company is preparing to enroll 220 patients with Crohn’s disease in a midstage clinical trial. Participants will receive either a dose with 7,500 eggs from a pig whipworm or a placebo once every two weeks for 12 weeks.”

It sounds tough, and I don’t think i would offer to be a guniea pig, but like I said, Pain is a great motivator. Is your

What do you think?

Prednivite | Reduce Prednisone Side Effects?

Written by mike on . Posted in Blog

Prednisone an corticosteroids are used all of the time in treating inflammation. If your normal NSAID’s don’t work,  most doctors won’t hesitate to prescribe Prednisone. ( other names for this type of corticosteroid include: medrol, dexamethasone, deltasone, orasone, liquid pred, and many more.)

The good and the bad is that there are many side effects associated with prednisone such as bone loss, weight gain, moodiness, agitation, irritability and many more. Lucklily it has been around for many years and is very well studied and documented. There is very little the medical comunity doesn’t know about prednisone.

I have personally been on and off of prednisone for years and get corticosteroid injections on a regular basis. When I ask doctors about side effects they usually give me the same old spiel…avoid salt, take calcium, get a lot of sleep etc… You know the drill! At my last visit my doctor recommended that i look into a supplement called Prednivite which is made specifically to reduce the negative side effects of prednisone.

I immediately purchased a few bottles and within a few weeks starting seeing results. If you are taking prednisone or just want a high quality supplement with nutrients that you need anyway, it may be worth a try.

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